Michael Hecker Selected Research

Starvation

1/2020	The Involvement of the McsB Arginine Kinase in Clp-Dependent Degradation of the MgsR Regulator in Bacillus subtilis.
1/2018	The Proteomic Response of Bacillus pumilus Cells to Glucose Starvation.
1/2016	Costs of life - Dynamics of the protein inventory of Staphylococcus aureus during anaerobiosis.
12/2014	A proteomic view of cell physiology of the industrial workhorse Bacillus licheniformis.
9/2014	Highly precise quantification of protein molecules per cell during stress and starvation responses in Bacillus subtilis.
7/2014	A time resolved metabolomics study: the influence of different carbon sources during growth and starvation of Bacillus subtilis.
3/2014	The phosphoproteome and its physiological dynamics in Staphylococcus aureus.
12/2013	Fermentation stage-dependent adaptations of Bacillus licheniformis during enzyme production.
9/2013	Common versus noble Bacillus subtilis differentially responds to air and argon gas plasma.
1/2013	Aureolib - a proteome signature library: towards an understanding of staphylococcus aureus pathophysiology.

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Michael Hecker Research Topics

Disease

39	Multiple Sclerosis 06/2022 - 12/2008
35	Starvation 01/2020 - 02/2003
17	Infections 04/2022 - 03/2008
7	Relapsing-Remitting Multiple Sclerosis 01/2019 - 12/2008
5	Disease Progression 01/2019 - 01/2011
4	Chronic Disease (Chronic Diseases) 03/2022 - 02/2020
4	Shock 09/2014 - 04/2005
3	Sepsis (Septicemia) 01/2018 - 05/2006
2	Neoplasms (Cancer) 01/2022 - 12/2009
2	Nervous System Diseases (Neurological Disorders) 06/2021 - 01/2021
2	Atrophy 01/2019 - 05/2008
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 02/2009
2	Pneumonia (Pneumonitis) 01/2017 - 01/2017
2	Type 2 Diabetes Mellitus (MODY) 01/2016 - 07/2015
2	Autoimmune Diseases (Autoimmune Disease) 01/2012 - 12/2008
2	Whooping Cough (Pertussis) 04/2011 - 01/2009
2	Breast Neoplasms (Breast Cancer) 03/2011 - 12/2009
2	Rheumatoid Arthritis 08/2009 - 01/2008
1	Communicable Diseases (Infectious Diseases) 04/2022
1	Parkinson Disease (Parkinson's Disease) 01/2021
1	Cognitive Dysfunction 01/2021
1	Frailty 01/2021
1	Dementia (Dementias) 01/2021
1	Dehydration (Water Stress) 01/2020
1	Acquired Immunodeficiency Syndrome (AIDS) 01/2020
1	Necrosis 01/2020
1	Encephalomyelitis (Myeloencephalitis) 01/2020
1	Prostatic Neoplasms (Prostate Cancer) 01/2020
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2019

Drug/Important Bio-Agent (IBA)

41	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2003
17	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 02/2003
15	ProteomeIBA 01/2022 - 02/2003
10	Pharmaceutical PreparationsIBA 03/2022 - 08/2014
8	CarbonIBA 01/2018 - 02/2003
8	Phosphates (Orthophosphate)IBA 12/2014 - 08/2004
7	EnzymesIBA 01/2020 - 05/2008
7	Amino Acids FDA Link 01/2017 - 08/2004
6	MicroRNAs (MicroRNA)IBA 06/2022 - 01/2012
6	Biomarkers (Surrogate Marker)IBA 01/2022 - 12/2008
4	Peptides (Polypeptides)IBA 01/2020 - 01/2012
4	Fingolimod Hydrochloride (FTY720)FDA Link 01/2018 - 01/2017
4	Interferon-betaIBA 01/2018 - 12/2008
3	VaccinesIBA 04/2022 - 01/2009
3	AntigensIBA 11/2018 - 10/2015
3	Sphingosine-1-Phosphate ReceptorsIBA 01/2018 - 01/2017
3	InterferonsIBA 01/2018 - 03/2011
3	CytokinesIBA 01/2017 - 10/2008
3	Immunoglobulin G (IgG)IBA 04/2016 - 10/2015
3	AntibodiesIBA 10/2015 - 05/2006
3	NitrogenIBA 12/2014 - 01/2006
3	Tryptophan (L-Tryptophan)FDA Link 09/2013 - 08/2006
3	Peptide Hydrolases (Proteases)FDA Link 01/2008 - 09/2004
2	Indicators and Reagents (Reagents)IBA 10/2021 - 06/2021
2	Triamcinolone Acetonide (Azmacort)FDA LinkGeneric 01/2020 - 01/2020
2	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2018 - 01/2017
2	Oligoclonal BandsIBA 04/2016 - 10/2015
2	Acarbose FDA LinkGeneric 01/2016 - 07/2015
2	Oxygen (Dioxygen)IBA 01/2016 - 05/2009
2	Ethanol (Ethyl Alcohol)IBA 12/2014 - 04/2005
2	Phosphorus (Red Phosphorus)IBA 07/2014 - 02/2007
2	Sigma FactorIBA 07/2014 - 03/2008
2	Virulence Factors (Pathogenicity Factors)IBA 03/2014 - 02/2010
2	Glatiramer Acetate (Copaxone)FDA Link 10/2013 - 03/2011
2	NitratesIBA 01/2013 - 02/2007
2	Membrane Proteins (Integral Membrane Proteins)IBA 09/2010 - 05/2008
2	Etanercept (Enbrel)FDA Link 08/2009 - 01/2008
2	SuperantigensIBA 10/2008 - 05/2006
2	polyacrylamideIBA 01/2008 - 01/2004
2	RNA (Ribonucleic Acid)IBA 01/2008 - 08/2006
2	6-Phytase (Phytase)IBA 02/2007 - 06/2006
2	Ammonium CompoundsIBA 01/2007 - 08/2006
1	Procainamide (Procan)FDA LinkGeneric 01/2022
1	Biological ProductsIBA 08/2021
1	Rituximab (Mabthera)FDA Link 01/2021
1	Mitoxantrone (Novantrone)FDA LinkGeneric 01/2021
1	SteroidsIBA 01/2021
1	Protein Sorting Signals (Signal Peptide)IBA 10/2020
1	Betaine (C.B.B.)FDA Link 01/2020
1	Metalloproteases (Metalloproteinases)IBA 01/2020
1	ethyleneIBA 01/2020
1	4- (4- dihexadecylaminostyryl)- N- methylpyridium (DiA)IBA 01/2020
1	Insulin-Like Growth Factor Binding Protein 3IBA 01/2020
1	Insulin-Like Growth Factor II (Somatomedin A)IBA 01/2020
1	Insulin-Like Growth Factor Binding Protein 2IBA 01/2020
1	TrypsinIBA 01/2020
1	Insulin-Like PeptidesIBA 01/2020
1	CarbohydratesIBA 01/2020
1	Adenosine Triphosphate (ATP)IBA 01/2020
1	Hypnotics and Sedatives (Sedatives)IBA 01/2019
1	InflammasomesIBA 01/2019
1	Gastrointestinal AgentsIBA 01/2019
1	HLA-DRB1 Chains (HLA DRB1)IBA 01/2019
1	Apolipoproteins E (ApoE)IBA 01/2019
1	Influenza Vaccines (Influenza Vaccine)FDA Link 01/2019

Therapy/Procedure

14	Therapeutics 01/2019 - 01/2008
7	Polypharmacy 03/2022 - 01/2019
1	Immunomodulation 04/2022
1	Deprescriptions 01/2021
1	Plasma Exchange 01/2021
1	Spinal Injections 01/2020